ODD, but probably related and keep the following in mind...
1. I am using an Alienware X51
2. It has an onboard Intel GPU
3. It has an nVidia GPU card added
4. Only one monitor
5. Multiple Displays is OFF
6. I am using Win 10
Periodically, programs will open in the taskbar but not display on the desktop. I have to Shift+Right-Click and then use the "Move" option to drag them into view. I was not able to track down the issue until this morning when I took a screenshot of a model in NWNExplorer to upload to another thread on the forums.
My desktop is set to a resolution of 1920x1080, yet when I took the screenshot, the image measured 2944x1080 and clearly showed another full-sized desktop sitting to the right of the desktop visible on my monitor. After a long winded search through Google, I was able to track down what was wrong and the solution. Windows 10 was taking the horizontal value from the resolution setting under nVidia Control Panel and adding it to the horizontal resolution setting under the Intel Graphics Control Panel, then using this combined value as the resolution - essentially tricking itself into thinking two screens were being used. The solution was to disable the Intel GPU in Device Manager.
Yup - Windows 10 - "the best experience you'll ever have..." Maybe if you like tracking down bugs. So in closing...
IF YOU HAVE AN ONBOARD GPU AND ARE USING A VIDEO CARD, DISABLE THE ONBOARD GPU IN DEVICE MANAGER.
And...just to connect this to NWN, my game is behaving much better now that I've disabled the Intel GPU.