There are quite a few bugs & exploits you should work on, or download a fix to, for Multi-Player, furthermore everything has to respawn, unlike a single player module, where if a PC kills something it's usually as good as dead, where in multi-player everything magically comes back to life.
Naturally you want to work on focusing on entertaining a large crowd, all too often single player modules are too focused on a specific type of player, or follow a theme, in Multi-Player, you should bring your best work, test & test some more, because a party of 5 players are going to bowl over most normal monsters, so naturally you should make higher quality monsters, not just put in some generic NWN Mobs, they will get owned fast.
Naturally everything has to be harder for the PCs in multi-player, you should build for parties but take care not to overwhelm people who travel alone. Often you will find builders who, having a monster who is very hard for one person, they choose to spawn in 3+ of these monsters on a PC, so the PC is completely & utterly dominated by the encounter, which is no fun at all.
If you want to build a good module, remember you are building for both parties of PCs & players who go it alone. Also, as a final tip, remember that X players can cause a lot of issues, especially if you don't have a powerful server computer, when you get 10+ player your scripting will really start to show, if it's buggy or laggy, the server could become consitpated, and you definitely do not want to leave NPCs laying around when PCs are done in an area, nor do you want to put a lot of placeable objects in your module.
Keep your stores all in one area where the PC's never enter, this way lag can be significantly reduced. The larger the map, the longer the loading time, the more people transitioning large maps, the more bandwidth will be consumed on your server, so keep your maps small to medium size, not huge! Huge is ok for some areas, but they should be few and far between.
Entertaining the crowd involves giving the crowd lots of things to do, too many builders build areas put little but some encounters in them, and call it a module, that's not entertaining at all. Entertainment should come in many forms, not just combat & puzzles. Everything comes into play even more in Multi-Player, remember you are building against a collective brain of players, not just one, so you can make it much more difficult, and if one PC cannot figure it out, maybe a group can, so don't worry about the complaining, solo players are going to have it rough and there is nothing you can do about that.
Hope this helped you some...